Abstract | BACKGROUND: OBJECTIVE: DESIGN, SETTING, AND PARTICIPANTS: A nested case-control study of participants of the Perindopril Protection Against Recurrent Stroke Study was performed. The Perindopril Protection Against Recurrent Stroke Study was a placebo-controlled trial of a perindopril erbumine-based, blood pressure-lowering regimen that reduced ischemic stroke risk by 24% among individuals with previous stroke or transient ischemic attack. Each of 252 patients who experienced ischemic stroke during a mean follow-up of 3.9 years was matched to 1 to 3 control patients. Matching variables were age, sex, treatment allocated, region, and most recent qualifying event at randomization. MAIN OUTCOME MEASURES: RESULTS: CONCLUSION: Measurement of sVCAM-1 and NT-proBNP levels provides prognostic information for recurrent ischemic stroke beyond traditional risk factors.
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Authors | Duncan J Campbell, Mark Woodward, John P Chalmers, Samuel A Colman, Alicia J Jenkins, Bruce E Kemp, Bruce C Neal, Anushka Patel, Stephen W MacMahon |
Journal | Archives of neurology
(Arch Neurol)
Vol. 63
Issue 1
Pg. 60-5
(Jan 2006)
ISSN: 0003-9942 [Print] United States |
PMID | 16286536
(Publication Type: Comparative Study, Journal Article, Multicenter Study, Research Support, N.I.H., Extramural, Research Support, Non-U.S. Gov't)
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Chemical References |
- Peptide Fragments
- Vascular Cell Adhesion Molecule-1
- pro-brain natriuretic peptide (1-76)
- Natriuretic Peptide, Brain
- C-Reactive Protein
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Topics |
- Aged
- C-Reactive Protein
(metabolism)
- Case-Control Studies
- Cerebrovascular Disorders
(complications, metabolism)
- Chromatography, High Pressure Liquid
(methods)
- Female
- Follow-Up Studies
- Humans
- International Cooperation
- Male
- Middle Aged
- Natriuretic Peptide, Brain
(blood)
- Odds Ratio
- Outcome Assessment, Health Care
(methods)
- Peptide Fragments
(blood)
- Predictive Value of Tests
- Stroke
(blood, diagnosis, etiology)
- Vascular Cell Adhesion Molecule-1
(blood)
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