[A case of cecal cancer with multiple liver metastases responding to irinotecan (CPT-11)/cisplatin (CDDP) combination therapy for elevation of CA19-9 after complete response (CR) by l-leucovorin(LV)/5-fluorouracil(5-FU) therapy].

Abstract

A 62-year-old woman complained of abdominal pain and diarrhea from February 2, 2002. She was diagnosed with advanced cecal cancer with simultaneous multiple liver metastases. The serum level of CA 19-9 was 420 U/ ml. Ileoceal resection with D3 lymphnode dissection. The replacement of reservoir for hepatic arterial infusion (HAI) was performed on February 2, 2002. As the dissemination was seen near the mesocolon at laparotomy, we could resect all together. Pathological examination demonstrated II, 5.0 x 2.5 cm, mod, se, INFgamma, ly(1), v(1), n(2), stage IV. Systemic l-leucovorin/5-fluorouracil (l-LV/5-FU) + HAI of weekly high-dose 5-FU combination therapy was initiated at postoperative 14 days. The serum CA 19-9 level decreased immediately but was not within the normal range. On abdominal computed tomography (CT), liver metastatic lesions decreased 9 9% on May 27, 2002 and disappeared on August 26, 2002. Though there were no signs of recurrence, the serum CA 19-9 level elevated as of October, 2002. Since the hepatic artery was occluded, HAI was discontinued on November 28, 2002. The serum CA 19-9 level elevated inspite of the continuation of the l-LV/5-FU therapy which we increased an amount of 5- FU. Thus, we changed low-dose irinotecan (CPT-11)/cisplatin (CDDP) therapy. The serum level of CA 19-9 decreased gradually and got with in normal range on March, 2004. It did not elevate since then. Low-dose CPT-11/CDDP therapy may be useful for patients with advanced colon cancer thought to be resistant to 5-FU as second-line chemotherapy.

• Authors: Yoshikazu Fukuda, Nagahisa Fujio, Toshio Ihara, Hiroshi Takatori, Takashi Tsukazaki, Ikuho Koyama, Yoshito Tsukazaki, Harushi Osugi
• Journal: Gan to kagaku ryoho. Cancer & chemotherapy (Gan To Kagaku Ryoho) Vol. 32 Issue 12 Pg. 1949-52 (Nov 2005) ISSN: 0385-0684 [Print] Japan
• PMID: 16282733 (Publication Type: Case Reports, Journal Article)

Chemical References

• CA-19-9 Antigen
• Irinotecan
• Cisplatin
• Leucovorin
• Fluorouracil
• Camptothecin

Topics

• Adenocarcinoma (drug therapy, secondary, surgery)
• Antineoplastic Combined Chemotherapy Protocols (therapeutic use)
• CA-19-9 Antigen (blood)
• Camptothecin (administration & dosage, analogs & derivatives)
• Cecal Neoplasms (drug therapy, pathology, surgery)
• Cisplatin (administration & dosage)
• Drug Administration Schedule
• Female
• Fluorouracil (administration & dosage)
• Hepatic Artery
• Humans
• Infusion Pumps, Implantable
• Irinotecan
• Leucovorin (administration & dosage)
• Liver Neoplasms (drug therapy, secondary)
• Middle Aged