Abstract | AIM: METHODS: RESULTS: ICP, PSM, ST and the expression of nNOS, iNOS, eNOS and PDE5 were significantly decreased in group B compared with those in group A (P 0.01). However, ICP, PSM and the expression of nNOS and iNOS were increased in groups C and D compared with those in group B (P 0.05). Changes in ST and the expression of eNOS and PDE5 were not significant (P 0.05) in groups C and D compared with those in group B. CONCLUSION: Oral treatment with icariin ( 98.6 % purity) for 4 weeks potentially improves erectile function. This effect is correlated with an increase in PSM and the expression of certain NOS in the CC of castrated rats. These results suggest that icariin may have a therapeutic effect on erectile dysfunction.
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Authors | Wu-Jiang Liu, Zhong-Cheng Xin, Hua Xin, Yi-Ming Yuan, Long Tian, Ying-Lu Guo |
Journal | Asian journal of andrology
(Asian J Androl)
Vol. 7
Issue 4
Pg. 381-8
(Dec 2005)
ISSN: 1008-682X [Print] China |
PMID | 16281085
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Drugs, Chinese Herbal
- Flavonoids
- RNA, Messenger
- Testosterone
- Nitric Oxide Synthase
- Nitric Oxide Synthase Type I
- Nitric Oxide Synthase Type II
- Nitric Oxide Synthase Type III
- Nos2 protein, rat
- 3',5'-Cyclic-GMP Phosphodiesterases
- Cyclic Nucleotide Phosphodiesterases, Type 5
- Pde5a protein, rat
- icariin
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Topics |
- 3',5'-Cyclic-GMP Phosphodiesterases
(genetics, metabolism)
- Animals
- Blood Pressure
- Cyclic Nucleotide Phosphodiesterases, Type 5
- Drugs, Chinese Herbal
(pharmacology)
- Erectile Dysfunction
(drug therapy, metabolism)
- Flavonoids
(pharmacology)
- Gene Expression Regulation, Enzymologic
(drug effects)
- Male
- Muscle, Smooth
(drug effects, physiology)
- Nitric Oxide Synthase
(genetics, metabolism)
- Nitric Oxide Synthase Type I
(genetics, metabolism)
- Nitric Oxide Synthase Type II
(genetics, metabolism)
- Nitric Oxide Synthase Type III
(genetics, metabolism)
- Orchiectomy
- Penile Erection
(drug effects)
- Penis
(drug effects, enzymology)
- Pressure
- RNA, Messenger
(analysis)
- Rats
- Rats, Wistar
- Testosterone
(blood)
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