Abstract | PURPOSE: MATERIALS AND METHODS: A total of 64 patients with interstitial cystitis meeting the National Institute of Diabetes and Digestive and Kidney Diseases criteria were enrolled in a randomized prospective study. Patients were randomized in a 1:1 ratio to 1.5 mg/kg CyA twice daily (27 women, 5 men) or 100 mg PPS 3 times daily (26 women, 6 men) for a period of 6 months. The primary end point was daily micturition frequency, and secondary end points were mean and maximal voided volume, number of nocturia episodes, O'Leary-Sant symptom and problem indexes, visual analogue scale for pain, and subjective global response assessment. RESULTS: CyA was superior to PPS in all clinical outcome parameters measured at 6 months. Micturition frequency in 24 hours was significantly reduced in the CyA arm compared to the PPS arm (-6.7 +/- 4.7 vs -2.0 +/- 5.1 times). The clinical response rate (according to global response assessment) was 75% for CyA compared to 19% for PPS (p <0.001). Although there were more adverse events in the CyA arm than in the PPS arm, 29 patients completed the 6-month followup in both groups. CONCLUSIONS:
|
Authors | Jukka Sairanen, Teuvo L J Tammela, Mikael Leppilahti, Markku Multanen, Ilkka Paananen, Kari Lehtoranta, Mirja Ruutu |
Journal | The Journal of urology
(J Urol)
Vol. 174
Issue 6
Pg. 2235-8
(Dec 2005)
ISSN: 0022-5347 [Print] United States |
PMID | 16280777
(Publication Type: Comparative Study, Journal Article, Randomized Controlled Trial, Research Support, Non-U.S. Gov't)
|
Chemical References |
- Anti-Inflammatory Agents, Non-Steroidal
- Immunosuppressive Agents
- Pentosan Sulfuric Polyester
- Cyclosporine
|
Topics |
- Adult
- Aged
- Anti-Inflammatory Agents, Non-Steroidal
(adverse effects, therapeutic use)
- Cyclosporine
(adverse effects, therapeutic use)
- Cystitis, Interstitial
(complications, drug therapy, epidemiology)
- Female
- Follow-Up Studies
- Humans
- Immunosuppressive Agents
(adverse effects, therapeutic use)
- Male
- Middle Aged
- Pentosan Sulfuric Polyester
(adverse effects, therapeutic use)
- Prospective Studies
- Syncope
(etiology, prevention & control)
- Treatment Outcome
|