TCM differentiation of syndrome in 131 cases of
chronic hepatitis B has been studied with molecular-
biological and immuno-histological techniques. The results showed that 94.6% cases of Gan-Yu Pi-Xu (stagnancy in the liver leading to diminished function of the spleen) type belonged to
chronic persistent hepatitis (CPH), whose coincidence rate of pathology of the liver biopsies with CPH was 69.2%; the positive rate of
HBeAg and/or HBV
DNA in sera was 61.5%, and the positive rates of
HBsAg and HBV
DNA in liver tissues were 69.2% (of which 44.4% appeared diffuse pattern morphologically) and 33.3% respectively. 75.5% cases of Gan-Shen
Yin-Xu (deficiency of Yin of the liver and kidney) type belonged to
chronic active hepatitis (CAH) and 88.5% of the cases were pathologically described as CAH, the positive rates of
HBeAg and/or HBV
DNA in serum and
HBsAg in liver tissues were all 80.8%, among which the diffuse pattern of
HBsAg accounted for 85.7%, which was higher than that in Gan-Yu Pi-Xu type (P less than 0.05), the positive rates of
HBcAg and HBV
DNA in liver tissues were 34.6% (of which 55.6% appeared cytoplasmic pattern) and 63.2% respectively, which was higher than that in Gan-Yu Pi-Xu type (P less than 0.05). 75.0% cases of Qi-Zhi Xue-Yu (stagnation of vital energy and stasis of blood) type belonged to CAH with early state
cirrhosis, its pathological changes in liver tissues were obvious, replication levels of HBV corresponded to the cases of Gan-Yu.Pi-Xu type.