Cefuroxime axetil versus placebo for children with acute respiratory infection and imaging evidence of sinusitis: a randomized, controlled trial.

Abstract

AIM:

To evaluate the efficacy of antibiotic treatment in children who presented in medical care with respiratory infection and had imaging evidence of sinusitis.

METHODS:

Eighty-two children (4-10 y) with acute respiratory symptoms and ultrasonography findings suggestive of acute rhinosinusitis were enrolled in a randomized, double-blind trial. The sinus findings were confirmed with plain radiographs. The children received either cefuroxime axetil in 125-mg capsules twice a day for 10 d or placebo. Main outcome measures were complete cure in 2 wk and absence of prolonged symptoms or complications.

RESULTS:

A total of 72 children (88%) completed follow-up. The sinusitis findings in the ultrasound could be confirmed with plain radiographs in 65 of the 72 patients (90%). The proportion of children completely cured by day 14 was similar in both groups (difference 6%, 95% confidence interval -16% to 29%). Similarly, there was no significant difference in the proportions of children who escaped prolonged disease and complications between the groups (difference 7%, -9% to 24%).

CONCLUSION:

A 10-d course of cefuroxime axetil offered no clinical benefit to children with an acute respiratory illness and imaging evidence of acute sinusitis.

• Authors: Aila Kristo, Matti Uhari, Jukka Luotonen, Eero Ilkko, Petri Koivunen, Olli-Pekka Alho
• Journal: Acta paediatrica (Oslo, Norway : 1992) (Acta Paediatr) Vol. 94 Issue 9 Pg. 1208-13 (Sep 2005) ISSN: 0803-5253 [Print] Norway
• PMID: 16278986 (Publication Type: Journal Article, Randomized Controlled Trial)

Chemical References

• Anti-Bacterial Agents
• Placebos
• Cefuroxime
• cefuroxime axetil

Topics

• Acute Disease
• Anti-Bacterial Agents (therapeutic use)
• Cefuroxime (analogs & derivatives, therapeutic use)
• Child
• Child, Preschool
• Double-Blind Method
• Female
• Humans
• Male
• Placebos
• Respiratory Tract Infections (complications, drug therapy)
• Sinusitis (complications, drug therapy)
• Time Factors
• Treatment Outcome