Abstract | INTRODUCTION: In a study conducted by Annane, patients with septic shock and unresponsive to adrenocorticotropic hormone stimulation receiving low-dose steroid therapy had prolonged survival but not significantly improved 28-day mortality. The present study examines intravenous steroid use in PROWESS (Recombinant Human Activated Protein C Worldwide Evaluation in Severe Sepsis) patients meeting the Annane enrollment criteria (AEC). METHODS: RESULTS:
Steroid-treated patients were older, had higher Acute Physiology and Chronic Health Evaluation scores and more organ dysfunctions, and were more commonly receiving mechanical ventilation. Among patients meeting AEC, regardless of steroid treatment (n = 97), mortality in the placebo and drotrecogin alfa (activated) groups was 38% (19/50) and 28% (13/47), respectively (relative risk [RR] = 0.73, 95% confidence interval [CI] 0.41-1.30). When using AEC but excluding the requirement for randomization within 8 hours of shock onset (n = 612), placebo mortality was 38% (118/313) and drotrecogin alfa (activated) mortality was 29% (88/299; RR = 0.78, 95% CI 0.62-0.98). Using AEC but excluding the 8-hour window and with steroids initiated at baseline and/or infusion (n = 228) resulted in mortality for placebo and drotrecogin alfa (activated) groups of 43% (51/118) and 33% (36/110), respectively (RR = 0.76, 95% CI 0.54-1.06). CONCLUSION: Patients with severe sepsis from the PROWESS trial who were likely to respond to low-dose steroids according to the AEC were those patients at a high risk for death. However, when using the AEC, regardless of steroid use, patients exhibited a survival benefit from treatment with drotrecogin alfa (activated).
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Authors | Howard Levy, Pierre-Francois Laterre, Becky Bates, Rebecca L Qualy |
Journal | Critical care (London, England)
(Crit Care)
Vol. 9
Issue 5
Pg. R502-7
(Oct 05 2005)
ISSN: 1466-609X [Electronic] England |
PMID | 16277711
(Publication Type: Journal Article, Randomized Controlled Trial)
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Chemical References |
- Anti-Inflammatory Agents, Non-Steroidal
- Protein C
- Recombinant Proteins
- Steroids
- drotrecogin alfa activated
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Topics |
- Age Factors
- Analysis of Variance
- Anti-Inflammatory Agents, Non-Steroidal
(therapeutic use)
- Chi-Square Distribution
- Humans
- Middle Aged
- Protein C
(therapeutic use)
- Recombinant Proteins
(therapeutic use)
- Shock, Septic
(drug therapy, mortality)
- Steroids
(therapeutic use)
- Survival
- Treatment Outcome
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