Inhibition of collagenase by naturally-occurring flavonoids.

Abstract

We examined the inhibitory activities of various flavonoids, including the flavanones, flavones/isoflavones and flavonols, on collagenase from Clostridium histolyticum to establish their therapeutic potential against skin inflammation and photoaging. In general, the flavonols were stronger inhibitors than the flavones/isoflavones, and this indicated the importance of the C-3 hydroxyl substitution. Quercetin was the most active flavonoid among those tested, and it showed an IC50 of 286 microM. These novel results suggest that certain flavonoids, particularly the flavonols, may prevent collagen breakdown by inhibiting collagenase in inflamed skin as well as photoaged skin.

• Authors: Bo Young Sin, Hyun Pyo Kim
• Journal: Archives of pharmacal research (Arch Pharm Res) Vol. 28 Issue 10 Pg. 1152-5 (Oct 2005) ISSN: 0253-6269 [Print] Korea (South)
• PMID: 16276971 (Publication Type: Comparative Study, Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Flavanones
• Flavones
• Flavonoids
• Flavonols
• Isoflavones
• Matrix Metalloproteinase Inhibitors
• Plant Extracts
• Collagenases

Topics

• Clostridium histolyticum (enzymology)
• Collagenases (metabolism)
• Dose-Response Relationship, Drug
• Flavanones (chemistry, isolation & purification, pharmacology)
• Flavones (chemistry, isolation & purification, pharmacology)
• Flavonoids (chemistry, isolation & purification, pharmacology)
• Flavonols (chemistry, isolation & purification, pharmacology)
• Isoflavones (chemistry, isolation & purification, pharmacology)
• Matrix Metalloproteinase Inhibitors
• Molecular Structure
• Plant Extracts (chemistry, isolation & purification, pharmacology)