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Nesiritide for pulmonary arterial hypertension with decompensated cor pulmonale.

Abstract
Pulmonary arterial hypertension complicated by decompensated cor pulmonale is a challenging clinical problem with few effective therapeutic options. B-type natriuretic peptide is a pluripotent hormone that promotes diuresis and natriuresis, vasodilates systemic and pulmonary vessels, and reduces circulating levels of endothelin and aldosterone. It may represent a possible therapeutic strategy for decompensated cor pulmonale in the same manner that it is used to treat decompensated left heart failure. The authors report their experience with B-type natriuretic peptide as adjunctive therapy for pulmonary arterial hypertension complicated by decompensated cor pulmonale. A detailed case report is presented followed by the evaluation of a series of 11 cases occurring in eight patients from December 2002 through April 2004.
AuthorsMartha S Kingman, Brenda S Thompson, Trixie Newkirk, Fernando Torres
JournalProgress in cardiovascular nursing (Prog Cardiovasc Nurs) Vol. 20 Issue 4 Pg. 168-72 ( 2005) ISSN: 0889-7204 [Print] United States
PMID16276140 (Publication Type: Case Reports, Journal Article)
Chemical References
  • Natriuretic Agents
  • Natriuretic Peptide, Brain
Topics
  • Adult
  • Aged
  • Blood Pressure (drug effects)
  • Body Weight (drug effects)
  • Cardiac Output (drug effects)
  • Clinical Nursing Research
  • Disease Progression
  • Drug Monitoring
  • Dyspnea (etiology)
  • Echocardiography, Transesophageal
  • Female
  • Heart Failure (etiology)
  • Humans
  • Hypertension, Pulmonary (complications, diagnostic imaging, drug therapy, physiopathology)
  • Infusions, Intravenous
  • Male
  • Middle Aged
  • Natriuretic Agents (pharmacology, therapeutic use)
  • Natriuretic Peptide, Brain (pharmacology, therapeutic use)
  • Pulmonary Heart Disease (etiology)
  • Pulmonary Wedge Pressure (drug effects)
  • Severity of Illness Index
  • Treatment Outcome

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