Somatic mutational analysis of DAX1 in testes from men with idiopathic azoospermia.

Abstract

Mutations in the orphan nuclear receptor DAX1 (NR0B1) cause X-linked adrenal hypoplasia congenital (AHC), a disorder characterized by primary adrenal failure, hypogonadotropic hypogonadism. and azoospermia. We tested the hypothesis that DAX1 somatic mutations in human testis may cause azoospermia. DAX1 sequencing analysis in 15 testicular biopsy samples from men with idiopathic nonobstructive azoospermia did not reveal mutations in the coding region of the gene. We conclude that somatic abnormalities in DAX1 are absent or uncommon in these patients.

• Authors: Giovanna Mantovani, Mario Mancini, Giacomo Gazzano, Anna Spada, Giovanni M Colpi, Paolo Beck-Peccoz, Luca Persani
• Journal: Fertility and sterility (Fertil Steril) Vol. 84 Issue 5 Pg. 1542-4 (Nov 2005) ISSN: 1556-5653 [Electronic] United States
• PMID: 16275267 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• DAX-1 Orphan Nuclear Receptor
• DNA-Binding Proteins
• NR0B1 protein, human
• Receptors, Retinoic Acid
• Repressor Proteins

Topics

• Adult
• DAX-1 Orphan Nuclear Receptor
• DNA Mutational Analysis (methods)
• DNA-Binding Proteins (genetics)
• Humans
• Male
• Mutation
• Oligospermia (genetics)
• Receptors, Retinoic Acid (genetics)
• Repressor Proteins (genetics)
• Testis (chemistry)