Treatment of neonatal renovascular hypertension with intravenous enalapril.

Abstract

Hypertension in the neonate is commonly related to renal disease. More specifically, renovascular hypertension in neonates is often associated with the placement of a umbilical artery catheter. Many medications, including angiotensin-converting enzyme (ACE) inhibitors, have been used in the treatment of neonatal hypertension. Captopril, an ACE inhibitor, is an oral agent that is effective in renovascular hypertension. We describe the use of intravenous enalapril, another ACE inhibitor, in successfully treating severe renovascular hypertension refractory to standard medical therapy in two term neonates.

• Authors: T Mason, M J Polak, L Pyles, M Mullett, C Swanke
• Journal: American journal of perinatology (Am J Perinatol) Vol. 9 Issue 4 Pg. 254-7 (Jul 1992) ISSN: 0735-1631 [Print] United States
• PMID: 1627214 (Publication Type: Case Reports, Journal Article)

Chemical References

• Nitroprusside
• Enalapril

Topics

• Catheterization, Peripheral (adverse effects)
• Enalapril (administration & dosage, therapeutic use)
• Heart Failure (etiology)
• Humans
• Hypertension, Renovascular (complications, drug therapy, etiology)
• Infant, Newborn
• Injections, Intravenous
• Kidney (diagnostic imaging)
• Male
• Nitroprusside (therapeutic use)
• Radionuclide Imaging
• Umbilical Arteries