Long-term transfusion of polymerized bovine hemoglobin in a Jehovah's Witness following chemotherapy for myeloid leukemia: a case report.

Abstract	A 52-year-old female Jehovah's Witness presented with relapsed secondary acute myeloid leukemia. Because of chemotherapy-induced anemia, she was infused with the bovine hemoglobin (Hb)-based oxygen carrier HBOC-201 (Biopure) as the sole means of transfusion support. HBOC-201 has only been used for management of acute hemorrhage, and its utility in providing longer term transfusion support is unknown. Over a period of 18 days, a total dose of 1230 g of HBOC-201 was delivered. Although the patient succumbed to the disease after 18 days of treatment, this case documents our experience with the highest dose and duration of HBOC-201 ever used. Although possible renal toxicity could not be definitively excluded, the homogeneous extraction of oxygen by the brain in the presence of and perhaps from HBOC-201 was demonstrated.
Authors	Yash P Agrawal, Matthew Freedman, Zbigniew M Szczepiorkowski
Journal	Transfusion (Transfusion) Vol. 45 Issue 11 Pg. 1735-8 (Nov 2005) ISSN: 0041-1132 [Print] United States
PMID	16271098 (Publication Type: Case Reports, Journal Article)
Chemical References	Anti-Bacterial Agents Antineoplastic Agents Blood Substitutes Hemoglobins Polymers polymerized bovine hemoglobin Erythropoietin HBOC 201 Hemosiderin
Topics	Animals Anti-Bacterial Agents (therapeutic use) Antineoplastic Agents (therapeutic use) Blood Substitutes (administration & dosage, therapeutic use) Blood Transfusion (methods) Bone Marrow (metabolism, pathology) Brain (diagnostic imaging, metabolism) Cattle Dose-Response Relationship, Drug Drug Administration Schedule Drug Therapy, Combination Erythropoietin (therapeutic use) Fatal Outcome Female Hemoglobins (administration & dosage, therapeutic use) Hemosiderin (metabolism) Humans Infusions, Intravenous Jehovah's Witnesses Leukemia, Myeloid (diagnostic imaging, metabolism, pathology, therapy) Middle Aged Oxygen Consumption (drug effects) Polymers (administration & dosage) Positron-Emission Tomography Radiography

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.

Realize the full power of the drug-disease research graph!