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Remission of severe antiphospholipid syndrome associated with non-Hodgkin's B-cell lymphoma after combined treatment with rituximab and chemotherapy.

Abstract
The association of lymphoid neoplasms and antiphospolipid antibodies (APA), with or without thromboembolic complications, has been reported in several cases. We describe one case of B-cell non-Hodgkinís lymphoma (NHL) in which the combination of rituximab with standard chemotherapy led to the complete remission of a severe hypercoagulable state associated with APA.
AuthorsDino Veneri, Achille Ambrosetti, Massimo Franchini, Federico Mosna, Giovanni Poli, Giovanni Pizzolo
JournalHaematologica (Haematologica) Vol. 90 Suppl Pg. ECR37 (Nov 2005) ISSN: 1592-8721 [Electronic] Italy
PMID16266928 (Publication Type: Case Reports, Journal Article)
Chemical References
  • Antibodies, Monoclonal
  • Antibodies, Monoclonal, Murine-Derived
  • Anticoagulants
  • Rituximab
  • Vincristine
  • Warfarin
  • Doxorubicin
  • Cyclophosphamide
  • Heparin
  • Prednisone
Topics
  • Antibodies, Monoclonal (therapeutic use)
  • Antibodies, Monoclonal, Murine-Derived
  • Anticoagulants (therapeutic use)
  • Antineoplastic Combined Chemotherapy Protocols (administration & dosage, therapeutic use)
  • Antiphospholipid Syndrome (etiology)
  • Combined Modality Therapy
  • Cyclophosphamide (administration & dosage)
  • Doxorubicin (administration & dosage)
  • Heparin (therapeutic use)
  • Humans
  • Immunotherapy
  • Lymphoma, B-Cell (complications, drug therapy, immunology, surgery)
  • Male
  • Middle Aged
  • Prednisone (administration & dosage)
  • Pulmonary Embolism (drug therapy, etiology)
  • Recurrence
  • Remission Induction
  • Rituximab
  • Splenectomy
  • Thrombophilia (drug therapy, etiology)
  • Thrombophlebitis (drug therapy, etiology)
  • Vincristine (administration & dosage)
  • Warfarin (therapeutic use)

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