Topiramate for phantom limb pain: a time-series analysis.

Abstract

There is growing evidence of topiramate's efficacy in treating neuropathic pain. This article reports a detailed analysis of the response of four amputee subjects with phantom limb pain. Individual time-series analyses revealed that three out of four amputee participants receiving topiramate had statistically significant decreases in pain, with the peak effect noted at 800 mg daily. This analysis supports a hypothesis that topiramate may be effective in reducing phantom limb pain, and suggests a definitive study is indicated.

• Authors: R Norman Harden, Tim T Houle, Thomas A Remble, Wendy Lin, Kenten Wang, Samuel Saltz
• Journal: Pain medicine (Malden, Mass.) (Pain Med) 2005 Sep-Oct Vol. 6 Issue 5 Pg. 375-8 ISSN: 1526-2375 [Print] England
• PMID: 16266358 (Publication Type: Case Reports, Journal Article, Randomized Controlled Trial)

Chemical References

• Anticonvulsants
• Topiramate
• Fructose

Topics

• Adult
• Aged
• Anticonvulsants (adverse effects, therapeutic use)
• Fructose (administration & dosage, analogs & derivatives, therapeutic use)
• Humans
• Male
• Middle Aged
• Neuralgia (drug therapy, psychology)
• Pain Measurement
• Phantom Limb (drug therapy, psychology)
• Pilot Projects
• Time Factors
• Topiramate