Hyperbaric oxygen-induced changes in bacterial translocation and acinar ultrastructure in rat acute necrotizing pancreatitis.

Abstract

BACKGROUND:

We aimed to investigate the effects of hyperbaric oxygen therapy on bacterial translocation and acinar cell ultrastructure in a rat model of acute necrotizing pancreatitis.

METHODS:

Forty-eight male Sprague-Dawley rats were randomly divided into three groups. Acute pancreatitis was induced in groups II and III. Groups I and II did not receive any treatment, and group III was treated with hyperbaric oxygen. All surviving animals were killed 48 h after the induction of pancreatitis. Bacterial translocation and histological and ultrastructural changes were determined.

RESULTS:

The incidence of bacterial translocation in group III was significantly lower in comparison with group II (P<0.001). Histopathological and ultrastructural injury scores were also significantly lower in group III (P<0.001 and P<0.04, respectively).

CONCLUSIONS:

Hyperbaric oxygen therapy displayed beneficial effects on pancreatic superinfection and or histopathological and ultrastructural changes in experimental necrotizing pancreatitis.

• Authors: Nuket Mas, Ahmet Turan Isik, M Refik Mas, Bilgin Comert, Ilker Tasci, Salih Deveci, Mustafa Ozyurt, Yuksel Ates, Levent Yamanel, Huseyin Doruk, Nuran Yener
• Journal: Journal of gastroenterology (J Gastroenterol) Vol. 40 Issue 10 Pg. 980-6 (Oct 2005) ISSN: 0944-1174 [Print] Japan
• PMID: 16261435 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Topics

• Animals
• Bacterial Translocation
• Hyperbaric Oxygenation
• Male
• Pancreatitis, Acute Necrotizing (microbiology, pathology)
• Rats
• Rats, Sprague-Dawley