Abstract | BACKGROUND: METHODS:
Urapidil was interindividually compared to dihydralazine in a total of 42 patients, at six participating clinical centres. Patients were randomly assigned to the treatment groups. Urapidil was administered at an initial dose of 12.5-25mg, dihydralazine was administered at a uniform initial dose of 5mg. Patients were closely monitored for the initial 24h of therapy. Until delivery and in the postpartal phase, mother and baby underwent four additional follow-up checks at regular intervals. RESULTS: Either drug was effective in lowering BP. Urapidil treatment proved to be better controllable. There were clear differences as to tolerability. In the urapidil group, one patient complained of headaches. In the dihydralazine group, six patients experienced adverse occurrences. Under dihydralazine treatment, some marked HR increases occurred, interpretable as reflectory tachycardia. CONCLUSIONS:
Urapidil proved to be equally effective as dihydralazine in lowering BP in patients with pre-eclampsia, but showed a better controllability and tolerability. Urapidil can hence be recommended as a promising alternative for patients with PIH.
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Authors | Juergen R Wacker, Barbara K Wagner, Volker Briese, Burkhard Schauf, Lothar Heilmann, Clemens Bartz, Hartmut Hopp |
Journal | European journal of obstetrics, gynecology, and reproductive biology
(Eur J Obstet Gynecol Reprod Biol)
Vol. 127
Issue 2
Pg. 160-5
(Aug 2006)
ISSN: 0301-2115 [Print] Ireland |
PMID | 16253414
(Publication Type: Journal Article, Multicenter Study, Randomized Controlled Trial)
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Chemical References |
- Antihypertensive Agents
- Piperazines
- urapidil
- Dihydralazine
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Topics |
- Adult
- Antihypertensive Agents
(adverse effects, therapeutic use)
- Blood Pressure
- Dihydralazine
(adverse effects, therapeutic use)
- Dose-Response Relationship, Drug
- Female
- Humans
- Hypertension
(drug therapy)
- Piperazines
(adverse effects, therapeutic use)
- Pre-Eclampsia
(drug therapy)
- Pregnancy
- Pregnancy Complications, Cardiovascular
(drug therapy)
- Pregnancy Outcome
- Prospective Studies
- Time Factors
- Treatment Outcome
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