[Disorders in learning and memory processes in the monkey model of Alzheimer's disease: the role of the cerebral cortex associative areas].

Abstract

Processes of novelty learning and keeping the results in Alzheimer's disease in two groups of rhesus-monkeys (three monkeys in each group), were studied: following neurotoxins administrati- on (I group) and saline administration (II group). In two months after the injections (the C1 stage), considerable differences between the groups were revealed in the task of differentiation among contour shapes. For the I group monkeys the learning was difficult: the correct decision making did not reach 85 %, and the probability of refusing to make a decision increased. For the II group monkeys the learning characteristics were not disturbed. In six months after the injections (the C3 stage) the differences between the groups in the task of differentiation among new stimuli (heads of two monkeys) remained at the same level. When studying characteristics of the operative memory associated with keeping the learning results achieved at the C1 stage, a considerable worsening of these characteristics was revealed: diminishing of the correct decision making probability at the C1 stage (actually to the level of 0.5), increase in the probability of refusing to make a decision. The structural-functional organization of interaction between sensory and cognitive processes in learning and keeping the information in the operative memory, is discussed in association with the control of motivation and attention system and the role of the cortex associative areas.

• Authors: K N Dudkin, I V Chueva, F N Makarov, T G Bich, A E Roher
• Journal: Rossiiskii fiziologicheskii zhurnal imeni I.M. Sechenova (Ross Fiziol Zh Im I M Sechenova) Vol. 91 Issue 8 Pg. 857-71 (Aug 2005) ISSN: 0869-8139 [Print] Russia (Federation)
• PMID: 16252682 (Publication Type: English Abstract, Journal Article)

Chemical References

• Neurotoxins

Topics

• Alzheimer Disease (chemically induced, physiopathology, psychology)
• Animals
• Cerebral Cortex (physiopathology)
• Disease Models, Animal
• Learning (physiology)
• Macaca mulatta
• Memory (physiology)
• Neurotoxins