Therapeutic effects of bacteriophage Cpl-1 lysin against Streptococcus pneumoniae endocarditis in rats.

Abstract

Cpl-1, a pneumococcal phage lytic enzyme, was tested in rats with experimental endocarditis due to Streptococcus pneumoniae WB4. High-dose regimen Cpl-1 eliminated pneumococci from blood within 30 min and decreased bacterial titers in vegetations (>4 log10 CFU/g) within 2 h. Rapid bacterial lysis induced by Cpl-1 treatment increased cytokine secretion noticeably.

• Authors: J M Entenza, J M Loeffler, D Grandgirard, V A Fischetti, P Moreillon
• Journal: Antimicrobial agents and chemotherapy (Antimicrob Agents Chemother) Vol. 49 Issue 11 Pg. 4789-92 (Nov 2005) ISSN: 0066-4804 [Print] United States
• PMID: 16251333 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't, Research Support, U.S. Gov't, Non-P.H.S.)

Chemical References

• Cytokines
• Enzymes
• lysin, streptococcus bacteriophage

Topics

• Animals
• Cytokines (biosynthesis)
• Endocarditis, Bacterial (drug therapy, microbiology)
• Enzyme Therapy
• Enzymes
• Pneumococcal Infections (drug therapy, microbiology)
• Rats