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Substituted phenanthrenes with basic amino side chains: a new series of anti-breast cancer agents.

Abstract
In the course of our search for new anti-breast cancer agents, substituted phenanthrenes with basic amino side chains were synthesized and some of them showed remarkable antiproliferative activity against ER +ve MCF-7 cell line with IC(50) in the range of 3.53-22.25 microM. One of the compounds 15 ca showed anti-breast cancer activity in 7,12-dimethylbenz[a]anthracene (DMBA) induced hormone-dependent mammary tumor in rat and the activity was comparable to that shown by tamoxifen.
Authors Shagufta, Ajay Kumar Srivastava, Ramesh Sharma, Rajeev Mishra, Anil Kumar Balapure, Puvvada S R Murthy, Gautam Panda
JournalBioorganic & medicinal chemistry (Bioorg Med Chem) Vol. 14 Issue 5 Pg. 1497-505 (Mar 01 2006) ISSN: 0968-0896 [Print] England
PMID16249093 (Publication Type: Comparative Study, Journal Article, Research Support, Non-U.S. Gov't)
Chemical References
  • Amino Acids
  • Antineoplastic Agents
  • Phenanthrenes
  • Tamoxifen
  • 9,10-Dimethyl-1,2-benzanthracene
Topics
  • 9,10-Dimethyl-1,2-benzanthracene (pharmacology)
  • Amino Acids (chemistry)
  • Animals
  • Antineoplastic Agents (pharmacology)
  • Breast Neoplasms (pathology)
  • Cell Line, Tumor
  • Inhibitory Concentration 50
  • Mammary Neoplasms, Experimental (chemically induced, drug therapy)
  • Models, Chemical
  • Phenanthrenes (chemical synthesis, pharmacology)
  • Rats
  • Tamoxifen (pharmacology)
  • Time Factors

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