Abstract |
In the course of our search for new anti- breast cancer agents, substituted phenanthrenes with basic amino side chains were synthesized and some of them showed remarkable antiproliferative activity against ER +ve MCF-7 cell line with IC(50) in the range of 3.53-22.25 microM. One of the compounds 15 ca showed anti- breast cancer activity in 7,12-dimethylbenz[a] anthracene (DMBA) induced hormone-dependent mammary tumor in rat and the activity was comparable to that shown by tamoxifen.
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Authors | Shagufta, Ajay Kumar Srivastava, Ramesh Sharma, Rajeev Mishra, Anil Kumar Balapure, Puvvada S R Murthy, Gautam Panda |
Journal | Bioorganic & medicinal chemistry
(Bioorg Med Chem)
Vol. 14
Issue 5
Pg. 1497-505
(Mar 01 2006)
ISSN: 0968-0896 [Print] England |
PMID | 16249093
(Publication Type: Comparative Study, Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Amino Acids
- Antineoplastic Agents
- Phenanthrenes
- Tamoxifen
- 9,10-Dimethyl-1,2-benzanthracene
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Topics |
- 9,10-Dimethyl-1,2-benzanthracene
(pharmacology)
- Amino Acids
(chemistry)
- Animals
- Antineoplastic Agents
(pharmacology)
- Breast Neoplasms
(pathology)
- Cell Line, Tumor
- Inhibitory Concentration 50
- Mammary Neoplasms, Experimental
(chemically induced, drug therapy)
- Models, Chemical
- Phenanthrenes
(chemical synthesis, pharmacology)
- Rats
- Tamoxifen
(pharmacology)
- Time Factors
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