[Relationship between basal core promoter combined point mutation of hepatitis B virus and TCM syndrome type].

Abstract

OBJECTIVE:

To investigate the relationship between basal core promoter (BCP) combined point mutation of hepatitis B virus (HBV) and TCM syndrome type.

METHODS:

One hundred and two patients with chronic hepatitis with positive HBV DNA and hadn't ever been treated by Lamivudine and interferon were differentiated according TCM syndrome differentiation into 5 types, two excess types (damp-heat blocking zhong-jiao type and blood stasis blocking collaterals type) and three deficiency types, gan-stagnation with pi-dificiency type, gan-shen yin-deficiency type and pi-shen yang-deficiency type. The serum HBV DNA, hepatic biochemical indexes, and the mutation of BCPnt 1762A-T and nt1764G-A combined point were determined, respectively.

RESULTS:

The variant strain positive rate detected in the excess type was significantly higher than that in the deficiency type, the highest rate appeared in patients of damp-heat blocking zhong-jiao type.

CONCLUSION:

BCP combined point mutation may be liable to happen in patients of TCM excess type, especially in patients of damp-heat blocking zhong-jiao type.

• Authors: Fei Zhou, Ling-tai Wang, Jian-jie Chen, Gang Zhao, Bin Zhang
• Journal: Zhongguo Zhong xi yi jie he za zhi Zhongguo Zhongxiyi jiehe zazhi = Chinese journal of integrated traditional and Western medicine (Zhongguo Zhong Xi Yi Jie He Za Zhi) Vol. 25 Issue 9 Pg. 777-9 (Sep 2005) ISSN: 1003-5370 [Print] China
• PMID: 16248235 (Publication Type: English Abstract, Journal Article)

Chemical References

• Hepatitis B Core Antigens

Topics

• Diagnosis, Differential
• Hepatitis B Core Antigens (genetics)
• Hepatitis B virus (genetics)
• Hepatitis B, Chronic (diagnosis, virology)
• Humans
• Medicine, Chinese Traditional
• Point Mutation
• Promoter Regions, Genetic (genetics)