Efficiency of olopatadine hydrochloride 0.1% in the treatment of vernal keratoconjunctivitis and goblet cell density.

Abstract

PURPOSE:

The aim of this study was to investigate the effect of topical 0.1% olopatadine hydrochloride on goblet cell density, clinical signs, and symptoms of patients with vernal keratoconjunctivitis.

METHODS:

Between December 2002 and April 2003, 40 eyes of 20 patients with vernal keratoconjunctivitis and 10 healthy eyes of 5 control patients were evaluated prospectively and treated with 0.1% olopatadine hydrochloride. Both groups were observed clinically, subjective complaints were recorded, and changes in goblet cell density were obtained with brush cytology.

RESULTS:

After the 2-month therapy, subjective complaints and clinical signs improved with therapy. Also, the clinical signs were improved with the therapy. As the severity of the signs and symptoms were reduced, goblet cell numbers in the brush cytologic specimens were reduced.

CONCLUSION:

Olopatadine hydrochloride 0.1% is an effective agent for relieving the signs and symptoms of vernal keratoconjunctivitis. Also, it reduces the number of goblet cells, which, in turn, decreases the amount of mucus discharge in vernal keratoconjunctivitis during treatment.

• Authors: Işik Corum, Bariş Yeniad, Lale Közer Bilgin, Ridvan Ilhan
• Journal: Journal of ocular pharmacology and therapeutics : the official journal of the Association for Ocular Pharmacology and Therapeutics (J Ocul Pharmacol Ther) Vol. 21 Issue 5 Pg. 400-5 (Oct 2005) ISSN: 1080-7683 [Print] United States
• PMID: 16245967 (Publication Type: Journal Article)

Chemical References

• Dibenzoxepins
• Histamine H1 Antagonists
• Olopatadine Hydrochloride

Topics

• Adult
• Cell Count
• Cell Degranulation
• Conjunctivitis, Allergic (drug therapy, pathology)
• Dibenzoxepins (therapeutic use)
• Female
• Histamine H1 Antagonists (pharmacology)
• Humans
• Male
• Mast Cells (drug effects, physiology)
• Middle Aged
• Olopatadine Hydrochloride
• Prospective Studies