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The efficacy of timolol in gel-forming solution after morning or evening dosing in Asian glaucomatous patients.

AbstractAIMS:
The aim of this study was to determine the effectiveness of timolol gel-forming solution as a monotherapy and to compare the efficacy of timolol gel-forming solution morning instillation versus at night application in Asians with newly diagnosed open-angle glaucoma.
METHODS:
A retrospective, comparative, parallel group study was conducted on 78 eligible patients diagnosed with open-angle glaucoma who received topical timolol gel-forming solution either on morning (AM dosing group; 39 patients) or evening (PM dosing group; 39 patients) as monotherapy treatment. Intraocular pressure was taken at baseline, 1, 3, 6, and 12 months post-treatment.
RESULTS:
Mean baseline intraocular pressure (IOP) for timolol gel-forming solution in general was 22.7 +/- 6.6 mmHg with the mean IOP reduction of 5.7 +/- 5.3 mmHg (23.1% reduction). The mean IOP reduction of the AM dosing group was 7.5 +/- 5.2 mmHg (31.0% reduction) and 3.9 +/- 4.9 mmHg (15.1% reduction) in the PM dosing group (P = 0.0002). There was a statistically significant difference of IOP reductions between AM and PM dosing group at 1 month (P = 0.041), 3 months (P = 0.037) and 12 months (P = 0.015) post-treatment. Seventy-five percent (24) of good responders was in the AM group and 67.4% (31) of poor responders were patients in the PM group.
CONCLUSION:
Timolol gel-forming solution is effective in reducing IOP in Asian eyes. Morning dosing was more effective in lowering the IOP compared to evening dosing.
AuthorsLieh Bin Ong, Ahmad Tajuddin Liza-Sharmini, Lee Ling Chieng, Min Tet Cheong, Selva Raja Vengadasalam, Hoy Choong Shin, Pillai Balaravi
JournalJournal of ocular pharmacology and therapeutics : the official journal of the Association for Ocular Pharmacology and Therapeutics (J Ocul Pharmacol Ther) Vol. 21 Issue 5 Pg. 388-94 (Oct 2005) ISSN: 1080-7683 [Print] United States
PMID16245965 (Publication Type: Comparative Study, Journal Article)
Chemical References
  • Gels
  • Timolol
Topics
  • Adult
  • Aged
  • Asian People
  • Female
  • Gels
  • Glaucoma, Open-Angle (drug therapy)
  • Humans
  • Intraocular Pressure (drug effects)
  • Male
  • Middle Aged
  • Retrospective Studies
  • Time Factors
  • Timolol (administration & dosage)

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