Activity of cathepsin D and alpha(1)-antitrypsin in the blood serum of patients with mammary carcinoma.
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| Abstract | UNLABELLED: THE AIM of this study was to determine the activity of cathepsin D and alpha(1)-antitrypsin in the blood serum of patients with mammary carcinoma. PATIENTS AND METHODS: The study was conducted on 52 women operated for a unilateral breast tumor, divided into two groups, according to the number of metastases and tumor size. Cathepsin D activity was determined using the method of Anson, while alpha(1)-antitrypsin activity was determined according to the Eriksson method. RESULTS: Both groups of patients with mammary carcinoma were found to have higher activity of cathepsin D before the treatment compared to healthy females. After the surgery the enzyme activity increased significantly, whereas 6 months after the surgery it generally decreased. The activity of alpha(1)-antitrypsin was significantly lower in patients before the treatment than in the controls, while after 6 months an increase in alpha(1)-antitrypsin activity was observed. The correlation between activity of cathepsin D and alpha(1)-antitrypsin was revealed. High enzyme activity and low alpha(1)-antitrypsin activity may result from the stage of neoplastic transformation. CONCLUSION: The determination of cathepsin D activity together with alpha(1)-antitrypsin activity may serve as useful biochemical marker in monitoring of malignant changes in breast tumor.
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| Authors | A Wozniak, C Mila-Kierzenkowska, D O Schachtschabel, B Wozniak, M Rozwodowska, T Drewa, S Drewa, J Sir, I Sir, R Maciak, E Krzyzynska-Malinowska |
| Journal | Experimental oncology (Exp Oncol) Vol. 27 Issue 3 Pg. 233-7 (Sep 2005) ISSN: 1812-9269 [Print] Ukraine |
| PMID | 16244588 (Publication Type: Journal Article) |
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