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Indole alkaloid marine natural products: an established source of cancer drug leads with considerable promise for the control of parasitic, neurological and other diseases.

Abstract
The marine environment produces natural products from a variety of structural classes exhibiting activity against numerous disease targets. Historically marine natural products have largely been explored as anticancer agents. The indole alkaloids are a class of marine natural products that show unique promise in the development of new drug leads. This report reviews the literature on indole alkaloids of marine origin and also highlights our own research. Specific biological activities of indole alkaloids presented here include: cytotoxicity, antiviral, antiparasitic, anti-inflammatory, serotonin antagonism, Ca-releasing, calmodulin antagonism, and other pharmacological activities.
AuthorsWaseem Gul, Mark T Hamann
JournalLife sciences (Life Sci) Vol. 78 Issue 5 Pg. 442-53 (Dec 22 2005) ISSN: 0024-3205 [Print] Netherlands
PMID16236327 (Publication Type: Journal Article, Research Support, N.I.H., Extramural, Research Support, Non-U.S. Gov't, Review)
Chemical References
  • Alkaloids
  • Anti-Infective Agents
  • Antineoplastic Agents
  • Antiparasitic Agents
  • Biological Products
  • Enzyme Inhibitors
  • Indoles
  • Neuroprotective Agents
  • Serotonin Agents
Topics
  • Alkaloids (chemistry, pharmacology, therapeutic use)
  • Animals
  • Anti-Infective Agents (chemistry, isolation & purification, pharmacology)
  • Antineoplastic Agents (chemistry, isolation & purification, pharmacology)
  • Antiparasitic Agents (chemistry, isolation & purification, pharmacology)
  • Biological Products (chemistry)
  • Enzyme Inhibitors (chemistry, isolation & purification, pharmacology)
  • Humans
  • Indoles (chemistry, pharmacology, therapeutic use)
  • Neoplasms (drug therapy, prevention & control)
  • Nervous System Diseases (drug therapy, prevention & control)
  • Neuroprotective Agents (chemistry, isolation & purification, pharmacology)
  • Parasitic Diseases (drug therapy)
  • Serotonin Agents (chemistry, isolation & purification, pharmacology)

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