Intrathecal baclofen for intractable spinal spasticity--a double-blind cross-over comparison with placebo in 6 patients.

Abstract

A group of six subjects with intractable spinal spasticity completed a double-blind cross-over paradigm in which they received two intrathecal bolus injections of baclofen solution five hours apart on two different days and two intrathecal bolus injections of placebo saline five hours apart on two other days. Each subject was repeatedly tested with a battery of clinical and physiological tests. In contrast to the placebo injections, the group responded to the baclofen injections with subjective and objective, clinically significant improvement in parameters of spasticity in their lower limbs, including muscle tone, frequency of spasms, hyperreflexia and passive range of joint motion. Furthermore, this improvement was maintained following thirty consecutive days of intrathecal bolus injections of baclofen at a fixed dose.

• Authors: H Hugenholtz, R F Nelson, E Dehoux, R Bickerton
• Journal: The Canadian journal of neurological sciences. Le journal canadien des sciences neurologiques (Can J Neurol Sci) Vol. 19 Issue 2 Pg. 188-95 (May 1992) ISSN: 0317-1671 [Print] England
• PMID: 1623444 (Publication Type: Clinical Trial, Journal Article, Randomized Controlled Trial, Research Support, Non-U.S. Gov't)

Chemical References

• Baclofen

Topics

• Adult
• Baclofen (administration & dosage, adverse effects, therapeutic use)
• Catheterization
• Disability Evaluation
• Double-Blind Method
• Female
• Humans
• Injections, Spinal
• Male
• Reflex (drug effects)
• Spinal Diseases (drug therapy, physiopathology)