Abstract | BACKGROUND: METHODS: Standardized measurements of urinary IgG, albumin, beta(2)M and alpha(1)M were performed at 0, 2, 6 and 12 months in 11 patients, at 12 months in 25 patients and in 17 of these last patients after 2-5 years. RESULTS: We observed a rapid improvement of glomerular permselectivity and tubular protein reabsorption within 2 months after the start of therapy. Despite a partial remission of proteinuria within 12 months in most patients, evidence of tubulo-interstitial injury remained apparent. Neither absolute levels of urinary IgG, beta(2)M or alpha(1)M at baseline or at 12 months nor the percentage reduction between baseline and 12 months clearly predicted the occurrence of a remission or a relapse to nephrotic range proteinuria. In the case of a persistent stable remission, we observed a gradual decrease of urinary beta(2)M towards normal values. CONCLUSIONS:
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Authors | Peggy W G du Buf-Vereijken, Jack F M Wetzels |
Journal | Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association
(Nephrol Dial Transplant)
Vol. 21
Issue 2
Pg. 389-96
(Feb 2006)
ISSN: 0931-0509 [Print] England |
PMID | 16234291
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Albumins
- Alpha-Globulins
- Glucocorticoids
- Immunoglobulin G
- alpha-1-microglobulin
- beta 2-Microglobulin
- Cyclophosphamide
- Prednisolone
- Methylprednisolone
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Topics |
- Aged
- Albumins
(metabolism)
- Alpha-Globulins
(urine)
- Cyclophosphamide
(therapeutic use)
- Follow-Up Studies
- Glomerulonephritis, Membranous
(drug therapy, urine)
- Glucocorticoids
(therapeutic use)
- Humans
- Immunoglobulin G
(urine)
- Male
- Methylprednisolone
(therapeutic use)
- Middle Aged
- Prednisolone
(therapeutic use)
- Renal Insufficiency
(drug therapy, urine)
- Time Factors
- beta 2-Microglobulin
(urine)
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