Abstract | OBJECTIVES: METHODS: Sixty consecutive patients with a symptomatic distal ureteral stone were included in our study and randomized to one of two home treatment groups. Group 1 patients ( n = 30) received tamsulosin (0.4 mg daily), and group 2 patients ( n = 30) were treated with a corticosteroid drug ( deflazacort, 30 mg daily) plus tamsulosin. The treatment duration was until stone expulsion or 28 days, whichever came first. The primary endpoint of the study was the stone expulsion rate. The secondary endpoints were the expulsion time; use of analgesics; number of emergency room admissions, hospitalizations, and workdays lost; drug side effects; and quality of life of the patients (EuroQol questionnaire, EQ-5D) during treatment. RESULTS: The two groups had a similar expulsion rate (90% for group 1 and 96.7% for group 2; P = 0.612), but the expulsion time was significantly reduced in group 2 patients (P = 0.036). During the treatment period, we did not observe significant differences between the two groups in the number of emergency room visits or hospitalizations, analgesic use, number of workdays lost, or incidence of drug side effects. The quality of life of the patients during therapy, as determined using the EQ-5D, was similar in both groups. CONCLUSIONS:
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Authors | Marco Dellabella, Giulio Milanese, Giovanni Muzzonigro |
Journal | Urology
(Urology)
Vol. 66
Issue 4
Pg. 712-5
(Oct 2005)
ISSN: 1527-9995 [Electronic] United States |
PMID | 16230122
(Publication Type: Journal Article, Randomized Controlled Trial)
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Chemical References |
- Adrenal Cortex Hormones
- Pregnenediones
- Sulfonamides
- Tamsulosin
- deflazacort
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Topics |
- Adrenal Cortex Hormones
(therapeutic use)
- Adult
- Drug Therapy, Combination
- Female
- Health Status Indicators
- Humans
- Male
- Middle Aged
- Pregnenediones
(therapeutic use)
- Prospective Studies
- Quality of Life
- Sulfonamides
(therapeutic use)
- Tamsulosin
- Ureteral Calculi
(drug therapy)
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