Osteonectin in osteosarcomas: a marker for differential diagnosis and/or prognosis?

Abstract

Seventy-five osteosarcomas at various grades of histologic differentiation were investigated for evidence of osteonectin. According to the results of the study, osteonectin was present in all osteosarcomas. An association between the intensity of the osteonectin antibody reaction and prognosis could not be established. Evidence of osteonectin was also found in other bone tumors. Osteonectin is therefore unsuitable for differential diagnosis, cannot be regarded as a bone specific protein and has not prognostic value.

• Authors: P Wuisman, A Roessner, A Bosse, Y Ueda, W Winkelmann, W F Enneking
• Journal: Annals of oncology : official journal of the European Society for Medical Oncology (Ann Oncol) Vol. 3 Suppl 2 Pg. S33-5 (Apr 1992) ISSN: 0923-7534 [Print] England
• PMID: 1622861 (Publication Type: Journal Article)

Chemical References

• Biomarkers, Tumor
• Osteonectin

Topics

• Biomarkers, Tumor (analysis)
• Bone Neoplasms (chemistry, diagnosis)
• Diagnosis, Differential
• Humans
• Immunohistochemistry
• Osteonectin (analysis)
• Osteosarcoma (chemistry, diagnosis)
• Prognosis