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Linezolid-associated serotonin syndrome: what we can learn from cases reported so far.

AbstractOBJECTIVES:
To study the characteristics of the linezolid-associated serotonin syndrome cases.
METHODS:
Database search for linezolid-associated serotonin syndrome.
RESULTS:
Twelve cases were found. The mean age of patients was 52.8 years. All patients received linezolid concomitantly with selective serotonin re-uptake inhibitor drugs (SSRID). The onset of syndrome was 9.5 days after linezolid introduction and was directly correlated to patients' age (P = 0.024). The symptoms resolved in 2.9 days. Citalopram was associated with a delayed resolution (P = 0.018). A trend was observed towards longer resolution time the longer the half-life of the interacting drug (P = 0.096).
CONCLUSIONS:
Patients are at risk when receiving SSRID concomitant with linezolid. The syndrome onset could be delayed in older patients. The resolution could be delayed when citalopram is involved in the syndrome.
AuthorsJosé Antonio Morales-Molina, Javier Mateu-de Antonio, Mónica Marín-Casino, Santiago Grau
JournalThe Journal of antimicrobial chemotherapy (J Antimicrob Chemother) Vol. 56 Issue 6 Pg. 1176-8 (Dec 2005) ISSN: 0305-7453 [Print] England
PMID16223940 (Publication Type: Journal Article)
Chemical References
  • Acetamides
  • Anti-Bacterial Agents
  • Oxazolidinones
  • Serotonin Uptake Inhibitors
  • Citalopram
  • Linezolid
Topics
  • Acetamides (administration & dosage, adverse effects)
  • Adult
  • Age Factors
  • Aged
  • Aged, 80 and over
  • Anti-Bacterial Agents (adverse effects)
  • Bacterial Infections (drug therapy)
  • Child, Preschool
  • Citalopram (adverse effects)
  • Female
  • Half-Life
  • Humans
  • Linezolid
  • Male
  • Middle Aged
  • Oxazolidinones (administration & dosage, adverse effects)
  • Serotonin Syndrome (etiology)
  • Selective Serotonin Reuptake Inhibitors (administration & dosage)

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