[Correlation of GST-pi and PCNA expression to prognosis of advanced maxillary sinus squamous cell carcinoma].

Abstract

BACKGROUND & OBJECTIVE:

Tumor markers which relate to cell proliferation and metabolism have seldom been studied in maxillary sinus cancer. This study was conducted to identify the correlation of glutathione S-transferase pi (GST-pi) and proliferating cell nuclear antigen (PCNA) expression to prognosis of advanced maxillary sinus squamous cell carcinoma (SCC).

METHODS:

The expression of GST-pi and PCNA in 54 specimens of maxillary sinus SCC, 29 specimens of benign maxillary tumor, and 20 specimens of normal nasal mucosa was detected by immunohistochemistry. The correlation of GST-pi and PCNA expression to prognosis of advanced maxillary sinus SCC was analyzed by Kaplan-Meier method. The prognosis was analyzed by Cox multivariate model.

RESULTS:

The overexpression rates of GST-pi and PCNA were significantly higher in maxillary sinus SCC than in benign maxillary tumor and normal nasal mucosa (74.1% vs. 89.6% and 15.0%, P<0.01; 79.6% vs. 3.4% and 0, P<0.01). The 5-year survival rate was significantly higher in advanced maxillary sinus SCC patients with high expression of GST-pi than in the patients with low expression of GST-pi (34.5% vs. 21.2%, P=0.025); the difference between the patients with high and low expression of PCNA was not significant (18.0% vs. 27.0%, P=0.890). The expression of GST-pi was an independent prognostic factor of advanced maxillary sinus SCC (P=0.039, odds ratio>1).

CONCLUSION:

The overexpression of GST-pi is an independent prognostic factor of advanced maxillary sinus SCC, but that of PCNA isn't.

• Authors: Gui-Fang Guo, Ru-Hua Xie, An-Kui Yang, Zhi-Hua Chen, Qiu-Liang Wu, Wei-Wei Liu, Shen-Ming Ou, Liang-Ping Xia, Ming-Yuan Chen, Jin-Xin Zhang
• Journal: Ai zheng = Aizheng = Chinese journal of cancer (Ai Zheng) Vol. 24 Issue 10 Pg. 1267-71 (Oct 2005) China
• PMID: 16219146 (Publication Type: English Abstract, Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Biomarkers, Tumor
• Proliferating Cell Nuclear Antigen
• Glutathione S-Transferase pi

Topics

• Adult
• Aged
• Biomarkers, Tumor
• Carcinoma, Squamous Cell (metabolism, radiotherapy, surgery)
• Female
• Follow-Up Studies
• Glutathione S-Transferase pi (metabolism)
• Humans
• Male
• Maxillary Sinus Neoplasms (metabolism, radiotherapy, surgery)
• Middle Aged
• Nasal Mucosa (metabolism)
• Prognosis
• Proliferating Cell Nuclear Antigen (metabolism)
• Proportional Hazards Models
• Survival Rate