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Telithromycin for the treatment of acute bacterial maxillary sinusitis: a review of a new antibacterial agent.

AbstractOBJECTIVE:
Telithromycin, the first approved ketolide antibiotic, was developed to treat community-acquired respiratory tract infections, including acute bacterial maxillary sinusitis (ABMS). A previously published study showed that a 5-day course of 800 mg telithromycin once daily is as effective as a 10-day course in the treatment of ABMS.
MATERIALS AND METHODS:
Data were pooled from two controlled, multinational, prospective, randomized, double-blinded ABMS trials comparing 5-day telithromycin (800 mg once daily) with 10-day amoxicillin-clavulanate (500/125 mg 3 times daily) and cefuroxime axetil (250 mg twice daily). Clinical cure and bacteriologic eradication rates were compared by means of descriptive statistics.
RESULTS:
The clinical cure rate for telithromycin was 80.9% versus 77.4% for comparators; bacteriologic eradication rate for telithromycin was 84.9% versus 81.7% for comparators. Most adverse events were mild to moderate in intensity and, most commonly, gastrointestinal in nature.
CONCLUSIONS:
These results support the conclusion that 5 days of treatment with telithromycin is as safe and effective in patients with ABMS as a 10-day course of treatment with amoxicillin-clavulanate or cefuroxime axetil.
AuthorsGuy Tellier, Stephen A Brunton, Roomi Nusrat
JournalSouthern medical journal (South Med J) Vol. 98 Issue 9 Pg. 863-8 (Sep 2005) ISSN: 0038-4348 [Print] United States
PMID16217977 (Publication Type: Journal Article, Meta-Analysis, Research Support, Non-U.S. Gov't)
Chemical References
  • Anti-Bacterial Agents
  • Ketolides
  • telithromycin
  • cefuroxime axetil
  • Amoxicillin-Potassium Clavulanate Combination
  • Cefuroxime
Topics
  • Acute Disease
  • Adolescent
  • Adult
  • Aged
  • Amoxicillin-Potassium Clavulanate Combination (therapeutic use)
  • Anti-Bacterial Agents (therapeutic use)
  • Cefuroxime (analogs & derivatives, therapeutic use)
  • Double-Blind Method
  • Drug Administration Schedule
  • Female
  • Haemophilus influenzae (isolation & purification)
  • Humans
  • Ketolides (therapeutic use)
  • Male
  • Maxillary Sinusitis (drug therapy, microbiology)
  • Middle Aged
  • Moraxella (Branhamella) catarrhalis (isolation & purification)
  • Prospective Studies
  • Randomized Controlled Trials as Topic
  • Staphylococcus aureus (isolation & purification)
  • Streptococcus pneumoniae (isolation & purification)

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