Abstract | BACKGROUND: OBJECTIVE: DESIGN: PATIENTS: Cerebrospinal fluid samples from 61 patients were analyzed. The group was composed of patients with CJD (n = 20), patients with other forms of dementia (n = 10), patients with motoneuron disease (n = 6), patients with normal pressure hydrocephalus (n = 5), and control subjects (n = 20). RESULTS:
Interleukin 10 levels were significantly elevated in the cerebrospinal fluid of CJD patients (median, 9.8 pg/mL). The elevation was significant to other dementia (median, 7.9 pg/mL, P<.05), motoneuron disease (median, 7.9 pg/mL, P<.05), normal pressure hydrocephalus (median, 7.0 pg/mL, P<.05), and controls (median, 1.3 pg/mL, P<.001). Levels of interleukin 4 were significantly elevated in cerebrospinal fluid of patients with CJD (median, 26.4 pg/mL) compared with control subjects (median, 6.2 pg/mL, P<.001) and patients with a motoneuron disease (median, 10.5 pg/mL, P<.001) CONCLUSIONS: Elevated levels of the anti-inflammatory cytokines interleukin 4 and interleukin 10 in cerebrospinal fluid of patients with CJD are new findings. The data of the present study provide a clue toward the possible role of cytokines as immunological modifiers in the neurodegenerative process of CJD.
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Authors | Katharina Stoeck, Monika Bodemer, Barbara Ciesielczyk, Bettina Meissner, Mario Bartl, Uta Heinemann, Inga Zerr |
Journal | Archives of neurology
(Arch Neurol)
Vol. 62
Issue 10
Pg. 1591-4
(Oct 2005)
ISSN: 0003-9942 [Print] United States |
PMID | 16216944
(Publication Type: Comparative Study, Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Interleukin-10
- Interleukin-4
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Topics |
- Adult
- Aged
- Creutzfeldt-Jakob Syndrome
(cerebrospinal fluid)
- Dementia
(cerebrospinal fluid)
- Enzyme-Linked Immunosorbent Assay
- Female
- Humans
- Hydrocephalus, Normal Pressure
(cerebrospinal fluid)
- Interleukin-10
(cerebrospinal fluid)
- Interleukin-4
(cerebrospinal fluid)
- Male
- Middle Aged
- Motor Neuron Disease
(cerebrospinal fluid)
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