Abstract | BACKGROUND/AIMS: High sodium consumption has been repeatedly reported to exert deleterious effects on severe chronic renal failure progression, mainly via glomerular mechanisms. However, the role of high sodium intake in renal function deterioration in a model of moderate chronic tubulointerstitial disease has not yet been addressed. We evaluated the effects of exaggerated dietary sodium and the resultant increase in proteinuria on renal function deterioration in experimental tubulointerstitial disease in rats. METHODS: In 48 Sprague-Dawley rats, moderate renal failure (approximately 50% of normal glomerular filtration rate) was induced by administration of lithium chloride in drinking water. The animals were divided into three groups fed low (<0.2% Na(+)), normal (0.5% Na(+)), or high (8% Na(+)) sodium diets. RESULTS: Animals in all groups remained normotensive with a similar course of GFR downslope and 100% survival, irrespective of sodium regimen. Rats consuming high sodium diets developed significantly greater proteinuria compared to their counterparts fed normal or low sodium chow. CONCLUSIONS:
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Authors | Joshua Weissgarten, Sylvia Berman, Shai Efrati, Michael Rapoport, Mordechay Aladjem, David Modai, Ahuva Golik, Natan Cohen, Elena Galperin, Zhan Averbukh |
Journal | American journal of nephrology
(Am J Nephrol)
2005 Nov-Dec
Vol. 25
Issue 6
Pg. 541-7
ISSN: 0250-8095 [Print] Switzerland |
PMID | 16205053
(Publication Type: Journal Article)
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Chemical References |
- Sodium Chloride, Dietary
- Lithium Chloride
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Topics |
- Animals
- Blood Pressure
(drug effects)
- Disease Models, Animal
- Disease Progression
- Glomerular Filtration Rate
- Kidney
(pathology)
- Kidney Failure, Chronic
(chemically induced, pathology, physiopathology)
- Lithium Chloride
- Male
- Nephritis, Interstitial
(chemically induced, pathology, physiopathology)
- Proteinuria
(chemically induced)
- Rats
- Rats, Sprague-Dawley
- Sodium Chloride, Dietary
(administration & dosage, pharmacology, urine)
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