[Study on classification and treatment of vulvovaginal candidiasis].

Abstract

OBJECTIVE:

To determine the clinical manifestations of vulvovaginal candidiasis (VVC) and to study the mycologic eradication rate of different miconazole treatment courses for VVC.

METHODS:

Three hundred cases of VVC were recruited. The Candidas were cultured. A prospective and randomized study was performed to compare the treatment effect of 3 day miconazole (400 mg/d), 6 day miconazole (400 mg/d), and 7 day miconazole (200 mg/d) for uncomplicated and complicated VVC.

RESULTS:

Among 300 cases of VVC, uncomplicated, complicated and recurrent VVC were 56.0%, 44.0% and 9.7% (29/300) respectively. C. albicans was isolated most frequently 90.3% (271/300), followed by C. glabrata (7.3%), C. tropicalis (1.3%), C. krusei (0.7%), and C. parapsilosis (0.3 %). Mycologic eradication rate of 3 day, 6 day and 7 day miconazole courses for uncomplicated VVC at day 14 was 96.0%, 93.5% and 98.0%, respectively (P > 0.05). Eradication rate of 3 day, 6 day and 7 day miconazole courses for complicated VVC at day 14 was 86.7%, 92.5%, and 86.4%, respectively (P > 0.05). Eradication rate of 3 day, 6 day and 7 day miconazole courses for uncomplicated VVC at day 35 was 93.8%, 95.3%, and 89.8%, respectively (P > 0.05). Eradication rate of 3 day, 6 day and 7 day miconazole courses for complicated VVC at day 35 was 89.7%, 97.3% and 86.8%, respectively (P > 0.05).

CONCLUSION:

Treatment of VVC should be individualized, and women with complicated VVC achieve superior mycologic eradication by a 6 day miconazole course.

• Authors: Shang-rong Fan, Xiao-ping Liu, Jian-wu Li, An-ping Xu, Miao Liu
• Journal: Zhonghua fu chan ke za zhi (Zhonghua Fu Chan Ke Za Zhi) Vol. 40 Issue 8 Pg. 532-5 (Aug 2005) ISSN: 0529-567X [Print] China
• PMID: 16202291 (Publication Type: Journal Article, Randomized Controlled Trial)

Chemical References

• Antifungal Agents
• Miconazole

Topics

• Adult
• Antifungal Agents (pharmacology, therapeutic use)
• Candida albicans (drug effects, isolation & purification)
• Candidiasis, Vulvovaginal (drug therapy, microbiology)
• Female
• Humans
• Miconazole (pharmacology, therapeutic use)
• Middle Aged
• Vagina (microbiology)