Endodermal sinus tumor of the vagina.

Abstract

Malignant germ cell tumors of the vagina represent a critical site for local treatment. We report on our experience with two vaginal endodermal sinus tumors. Treatment with PEB regimen induced both tumor regression and alpha fetoprotein normalization. One patient had a residual lesion that was biopsied twice and no viable tumor cells were ever found. Both patients remained alive and disease-free, without having had surgical procedures except for biopsies. Platinum-based chemotherapy is able to achieve complete remissions and should be considered for vaginal endodermal sinus tumors.

• Authors: Monica Terenziani, Filippo Spreafico, Paola Collini, Cristina Meazza, Maura Massimino, Luigi Piva
• Journal: Pediatric blood & cancer (Pediatr Blood Cancer) Vol. 48 Issue 5 Pg. 577-8 (May 2007) ISSN: 1545-5009 [Print] United States
• PMID: 16200632 (Publication Type: Case Reports, Journal Article)

Chemical References

• Bleomycin
• Etoposide
• Cisplatin

Topics

• Antineoplastic Combined Chemotherapy Protocols (therapeutic use)
• Bleomycin (administration & dosage)
• Child, Preschool
• Cisplatin (administration & dosage)
• Endodermal Sinus Tumor (drug therapy)
• Etoposide (administration & dosage)
• Female
• Humans
• Infant
• Remission Induction
• Vaginal Neoplasms (drug therapy)