Abstract | OBJECTIVE: METHODS: HLA typing was performed for 377 patients from the Leiden Early Arthritis Clinic who were diagnosed as having RA within the first year of followup (206 anti-CCP-positive patients and 171 anti-CCP-negative patients), 235 patients who, after 1 year, had undifferentiated arthritis (UA) (28 anti-CCP-positive patients and 207 anti-CCP-negative patients), and 423 healthy control subjects. Odds ratios ( ORs) with 95% confidence intervals (95% CIs) for HLA-DRB1 allele frequencies were determined for all patient groups compared with the healthy control group. RESULTS:
HLA-DR3 was more frequently present in the anti-CCP-negative RA group than in the control group (OR 1.84, 95% CI 1.26-2.67). This was not the case for anti-CCP-positive RA (OR 0.92, 95% CI 0.60-1.40). HLA-DR3 was also more frequently present in anti-CCP-negative UA patients (OR 1.59, 95% CI 1.10-2.28), but not in anti-CCP-positive UA patients (OR 0.68, 95% CI 0.17-1.92). CONCLUSION:
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Authors | Kirsten N Verpoort, Floris A van Gaalen, Annette H M van der Helm-van Mil, Geziena M T Schreuder, Ferdinand C Breedveld, Tom W J Huizinga, Rene R P de Vries, Rene E M Toes |
Journal | Arthritis and rheumatism
(Arthritis Rheum)
Vol. 52
Issue 10
Pg. 3058-62
(Oct 2005)
ISSN: 0004-3591 [Print] United States |
PMID | 16200610
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Autoantibodies
- HLA-DR3 Antigen
- Peptides, Cyclic
- cyclic citrullinated peptide
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Topics |
- Adolescent
- Adult
- Aged
- Aged, 80 and over
- Arthritis, Rheumatoid
(epidemiology, genetics, immunology)
- Autoantibodies
- Female
- Gene Frequency
- HLA-DR3 Antigen
(genetics)
- Humans
- Male
- Middle Aged
- Peptides, Cyclic
(immunology)
- Risk Factors
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