Abstract | OBJECTIVES: METHOD: 22 MG patients in Nottingham and 75 in Santiago who had a thymectomy were identified and their notes reviewed. We compared the median age, stage of disease, thymic histology and clinical outcome at two years post- thymectomy. RESULTS: The median ages for the Cuban and Nottingham patients were 25 and 35 years respectively. The median stage of disease was IIa by Osserman's classification in both. In Nottingham, 59% (13/22) showed an improvement compared with 88 % (66/75) in Santiago (p < 0.01). There were significantly more cases of thymoma in Nottingham whereas thymic hyperplasia and atrophy were a more frequent finding in Cuban patients. The majority of cases who improved post- thymectomy had thymic hyperplasia on histology in both Nottingham (46%) and Cuban (61%) patients. CONCLUSION: Selecting MG patients based on thymic enlargement alone or AchR antibody positivity may be inadequate and thymectomy should perhaps be considered in all patients with generalised myasthenia.
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Authors | N Shahrizaila, O A Pacheco, D G Vidal, F R Miyares, A J Wills |
Journal | Journal of neurology
(J Neurol)
Vol. 252
Issue 10
Pg. 1262-6
(Oct 2005)
ISSN: 0340-5354 [Print] Germany |
PMID | 16200466
(Publication Type: Comparative Study, Journal Article)
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Chemical References |
- Autoantibodies
- Receptors, Cholinergic
|
Topics |
- Adult
- Age Factors
- Atrophy
- Autoantibodies
(analysis)
- Cuba
- Female
- Follow-Up Studies
- Humans
- Hyperplasia
(pathology)
- Male
- Myasthenia Gravis
(complications, diagnosis, immunology, pathology, surgery)
- Receptors, Cholinergic
(immunology)
- Retrospective Studies
- Statistics, Nonparametric
- Thymectomy
- Thymoma
(complications)
- Thymus Gland
(pathology)
- Thymus Neoplasms
(complications)
- Time Factors
- Tomography, X-Ray Computed
- Treatment Outcome
- United Kingdom
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