Production of Ac-225 from Th-229 for targeted alpha therapy.

This work describes a method for the separation and purification of Ac-225 from a Th-229 source. The procedure is based on the combination of ion exchange and extraction chromatographic methods in nitric acid media and allows the preparation of carrier-free, clinical grade Ac-225 with an overall yield exceeding 95%. Quality control of the product is performed using radiometric (alpha, gamma spectrometry) and mass spectrometric methods. The Ac-225 product can be loaded on a radionuclide generator for the preparation of Bi-213 for preclinical and clinical studies of targeted alpha therapy of cancer and infectious diseases.
AuthorsC Apostolidis, R Molinet, G Rasmussen, A Morgenstern
JournalAnalytical chemistry (Anal Chem) Vol. 77 Issue 19 Pg. 6288-91 (Oct 1 2005) ISSN: 0003-2700 [Print] United States
PMID16194090 (Publication Type: Journal Article)
Chemical References
  • Anions
  • Radioisotopes
  • Thallium
  • Actinium
  • Actinium (chemistry, isolation & purification, therapeutic use)
  • Anions (chemistry)
  • Radioisotopes (chemistry)
  • Thallium (chemistry, therapeutic use)

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