Abstract |
In the present study, the cardiovascular activity of the aqueous extract of Gynostemma pentaphyllum Makino leaves was investigated in the anaestetized guinea-pigs and has been compared with two of its isolated gypenosides (III, VIII) and with verapamil, a well-known Ca-antagonistic drug. The results obtained showed that the intravenous administration of the decoction of G. pentaphyllum (2.5, 5 and 10mg/kg) produced a protective effect against pitressin-induced coronaryspasm, arrhythmias and pressor response. Extract also increased the dose of ouabain required to cause ventricular tachyarrhythmias and lethality. Further extract reversed ouabain-induced persistent ventricular tachycardia and restored sinus rhythm in a dose-dependent manner. The results obtained have also shown that gypenosides III and VIII caused similar protective effects in both experimental models used; however, the duration of the action is lower than that of the extract containing corresponding quantities of gypenosides III and VIII.
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Authors | C Circosta, R De Pasquale, F Occhiuto |
Journal | Phytomedicine : international journal of phytotherapy and phytopharmacology
(Phytomedicine)
Vol. 12
Issue 9
Pg. 638-43
(Sep 2005)
ISSN: 0944-7113 [Print] Germany |
PMID | 16194050
(Publication Type: Journal Article)
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Chemical References |
- Anti-Arrhythmia Agents
- Plant Extracts
- Vasopressins
- Verapamil
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Topics |
- Animals
- Anti-Arrhythmia Agents
(administration & dosage, pharmacology, therapeutic use)
- Arrhythmias, Cardiac
(chemically induced, prevention & control)
- Dose-Response Relationship, Drug
- Electrocardiography
- Guinea Pigs
- Gynostemma
- Male
- Phytotherapy
- Plant Extracts
(administration & dosage, pharmacology, therapeutic use)
- Plant Leaves
- Vasopressins
- Verapamil
(pharmacology)
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