Biological carrier improves passive protection of mice against Pseudomonas aeruginosa infection.

Abstract

In a model experiment, the use of specific hyperimmune globulins (SHG) alone failed to protect mice against infection with homologous and heterologous P. aeruginosa serotypes. However, the therapeutic potential of SHG dramatically improved after its conjugation with A1(OH)3, used as a biological carrier. The binding of SHG to this carrier proved to be the most effective and stable combination in the treatment of acute pseudomonad infections in mice.

• Authors: J Sourek, L Zelenková, J Pokorný
• Journal: Journal of hygiene, epidemiology, microbiology, and immunology (J Hyg Epidemiol Microbiol Immunol) Vol. 36 Issue 1 Pg. 105-10 ( 1992) ISSN: 0022-1732 [Print] Czech Republic
• PMID: 1619286 (Publication Type: Journal Article)

Chemical References

• Drug Carriers
• Immunoglobulins, Intravenous
• Aluminum Hydroxide

Topics

• Aluminum Hydroxide
• Animals
• Drug Carriers
• Hemagglutination (immunology)
• Immunization, Passive
• Immunoglobulins, Intravenous (administration & dosage, immunology, metabolism)
• Mice
• Pseudomonas Infections (immunology, prevention & control)