Bath-water PUVA therapy with 8-methoxypsoralen in mycosis fungoides.

Abstract

PUVA therapy is widely used for early stage mycosis fungoides. While the efficacy of PUVA with oral 8-methoxypsoralen (8-MOP) is well documented, the use of its topical variation, bath-water PUVA therapy with 8-MOP has not been studied. The purpose of this study was to assess the effect of 8-MOP bath-water PUVA therapy in adult patients with early stage mycosis fungoides. We retrospectively evaluated the outcomes of bath-water delivery of 8-MOP (1 mg l(-1)) in 16 patients with early stage mycosis fungoides. In all patients complete response was achieved after a mean duration of 63 days requiring 29 treatments and a mean cumulative UVA dose of 33 J cm(-2). The time to relapse after complete clinical clearance was 45.6 (+/-9.2) weeks. In comparison, oral PUVA therapy with 8-MOP resulted in complete response after 64.5 days (25.8 treatments) with a mean relapse-free period of 30 (+/-3.5) weeks. We conclude that bath-water PUVA therapy with 8-MOP is a valuable photo-therapeutic alternative, which should be considered for patients in whom systemic psoralen cannot be used.

• Authors: Florian Weber, Matthias Schmuth, Norbert Sepp, Peter Fritsch
• Journal: Acta dermato-venereologica (Acta Derm Venereol) Vol. 85 Issue 4 Pg. 329-32 ( 2005) ISSN: 0001-5555 [Print] Sweden
• PMID: 16191854 (Publication Type: Journal Article)

Chemical References

• Radiation-Sensitizing Agents
• Methoxsalen

Topics

• Administration, Cutaneous
• Administration, Oral
• Adult
• Aged
• Baths
• Female
• Humans
• Male
• Methoxsalen (administration & dosage)
• Middle Aged
• Mycosis Fungoides (drug therapy, pathology)
• PUVA Therapy
• Radiation Dosage
• Radiation-Sensitizing Agents (administration & dosage)
• Retrospective Studies
• Skin Neoplasms (drug therapy, pathology)
• Treatment Outcome