Abstract | CONTEXT: OBJECTIVE: The objective of this study was to evaluate the response of PCOS to the sustained and marked weight loss achieved by bariatric surgery in morbidly obese women. DESIGN: This was a longitudinal prospective nonrandomized evaluation. SETTINGS: The study was performed at an academic hospital. PATIENTS: Thirty-six consecutive premenopausal women submitted to bariatric surgery were screened for PCOS, which was present in 17. INTERVENTIONS: MAIN OUTCOME MEASURES: RESULTS:
Weight loss (41 +/- 9 kg after 12 +/- 5 months) was paralleled by decreases in the hirsutism score (from 9.5 +/- 6.8 to 4.9 +/- 4.2; P = 0.001), total (69 +/- 32 to 42 +/- 19 ng/dl; P < 0.02) and free testosterone (from 1.6 +/- 0.7 to 0.6 +/- 0.3 ng/dl; P < 0.005), androstenedione (from 4.1 +/- 1.5 to 3.0 +/- 0.9 ng/ml; P < 0.02), and dehydroepiandrosterone sulfate (from 2000 +/- 1125 to 1353 +/- 759 ng/ml; P < 0.005); amelioration of insulin resistance estimated by homeostasis model assessment (from 6.0 +/- 3.0 to 1.6 +/- 1.0; P < 0.001); and restoration of regular menstrual cycles and/or ovulation in all patients. CONCLUSIONS:
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Authors | Héctor F Escobar-Morreale, José I Botella-Carretero, Francisco Alvarez-Blasco, José Sancho, José L San Millán |
Journal | The Journal of clinical endocrinology and metabolism
(J Clin Endocrinol Metab)
Vol. 90
Issue 12
Pg. 6364-9
(Dec 2005)
ISSN: 0021-972X [Print] United States |
PMID | 16189250
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Topics |
- Adult
- Bariatric Surgery
- Cross-Sectional Studies
- Female
- Follow-Up Studies
- Humans
- Longitudinal Studies
- Obesity, Morbid
(complications, surgery)
- Polycystic Ovary Syndrome
(complications, physiopathology)
- Prospective Studies
- Remission Induction
- Weight Loss
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