Long-term remission of blastic natural killer-cell lymphoma after autologous peripheral blood stem-cell transplantation.

Abstract

We report here a case of blastic natural killer (NK)-cell lymphoma treated successfully with autologous peripheral blood stem-cell transplantation (APBSCT). A 57-year-old man had skin tumors and was diagnosed as having blastic NK-cell lymphoma by tumor biopsy. Skin, lymph nodes, left tonsil, and bone marrow were involved at presentation. Chemotherapy led to complete remission (CR). To sustain CR, the patient underwent high-dose chemotherapy in combination with 12 Gy of total-body irradiation (TBI) followed by autologous peripheral blood stem-cell rescue. He showed rapid recovery of hematopoiesis and could tolerate regimen-related toxicity after APBSCT. He has maintained long-term remission for 20 months after APBSCT. From this case, we concluded that APBSCT with preconditioning by TBI-containing regimens might be a cure-attaining treatment for disseminated blastic NK-cell lymphoma and should be considered as a choice of treatment in cases where no suitable donors for allogeneic transplantation are available.

• Authors: Masaki Yamaguchi, Mio Maekawa, Yoshihisa Nakamura, Mikio Ueda
• Journal: American journal of hematology (Am J Hematol) Vol. 80 Issue 2 Pg. 124-7 (Oct 2005) ISSN: 0361-8609 [Print] United States
• PMID: 16184583 (Publication Type: Case Reports, Journal Article)
• Copyright: (c) 2005 Wiley-Liss, Inc.

Topics

• Blast Crisis
• Hematopoiesis
• Humans
• Killer Cells, Natural (pathology)
• Lymphoma, T-Cell (pathology, therapy)
• Male
• Middle Aged
• Peripheral Blood Stem Cell Transplantation (methods)
• Remission Induction (methods)
• Skin Neoplasms
• Transplantation Conditioning (methods)
• Transplantation, Autologous
• Whole-Body Irradiation