[Control of the efficacy of the treatment of juvenile idiopathic generalized epilepsy and "pseudoremission"].

Abstract

The aim of the study was to evaluate efficacy of antiepileptic therapy (AT) in patients with juvenile types of idiopathic generalized epilepsy (IGE) and to elucidate factors that may reduce it. Forty-four patients with IGE, who received AT and were featured, according to self-rating and relative's estimation, by stopping of the seizures, have been studied. Prolonged video-EEG monitoring revealed a high frequency of registered epileptic seizures in the apparent remission: in 28 cases (59.5%) out of 47, there was epileptiform activity and in 16 (34%)--epileptic seizures. The results allowed us to formulate a definition of "pseudoremission"--a condition, which occurs in patients with epilepsy treated by antiepileptic drugs when the seizures are not diagnosed by the patient and his relatives. Criteria of pseudoremission are the following: a verified diagnosis of epilepsy, antiepileptic therapy, no seizures as assessed by the patient and relatives, VEM evidence of the present epileptic seizures. Pseudoremission requires urgent correction of antiepileptic therapy and prolongation of the treatment.

• Authors: M V Mironov, K Iu Mukhin, A S Petrukhin, A A Kholin
• Journal: Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova (Zh Nevrol Psikhiatr Im S S Korsakova) Vol. 105 Issue 8 Pg. 24-8 ( 2005) ISSN: 1997-7298 [Print] Russia (Federation)
• PMID: 16180495 (Publication Type: Comparative Study, English Abstract, Journal Article)

Chemical References

• Anticonvulsants

Topics

• Adolescent
• Adult
• Anticonvulsants (therapeutic use)
• Child
• Electroencephalography (methods)
• Epilepsy, Generalized (drug therapy, physiopathology)
• Female
• Follow-Up Studies
• Humans
• Male
• Remission Induction
• Treatment Outcome
• Video Recording