Adenocarcinoma ex pleomorphic adenoma of the head and neck: Report of five cases.

Abstract

OBJECTIVE:

Adenocarcinoma ex pleomorphic adenoma is a rare tumor, and thus the management of the tumor has not been established.

METHODS:

The retrospective review of the clinical records at Okayama University was performed.

RESULTS:

We present five cases of adenocarcinoma ex pleomorphic adenoma of the head and neck, including a rare case with nasopharyngeal adenocarcinoma ex pleomorphic adenoma. There was no response to chemotherapy with nedaplatin and 5-FU, but the nasopharyngeal adenocarcinoma ex pleomorphic adenoma showed a remarkable regression after the administration of docetaxel.

CONCLUSION:

The combination therapy that includes docetaxel may be a promising treatment for adenocarcinoma ex pleomorphic adenoma of the head and neck.

• Authors: Shin Kariya, Michiya Kosaka, Yorihisa Orita, Hirofumi Akagi, Kazunori Nishizaki
• Journal: Auris, nasus, larynx (Auris Nasus Larynx) Vol. 33 Issue 1 Pg. 43-6 (Mar 2006) ISSN: 0385-8146 [Print] Netherlands
• PMID: 16168590 (Publication Type: Journal Article)

Chemical References

• Organoplatinum Compounds
• Taxoids
• Docetaxel
• nedaplatin
• Fluorouracil

Topics

• Adenoma, Pleomorphic (pathology, therapy)
• Aged
• Aged, 80 and over
• Antineoplastic Combined Chemotherapy Protocols (therapeutic use)
• Docetaxel
• Female
• Fluorouracil (administration & dosage)
• Humans
• Male
• Middle Aged
• Mouth Neoplasms (pathology, therapy)
• Nasopharyngeal Neoplasms (pathology, therapy)
• Neoadjuvant Therapy
• Organoplatinum Compounds (administration & dosage)
• Palate (pathology)
• Parotid Gland (pathology)
• Retrospective Studies
• Taxoids (administration & dosage)