Alopecia areata treatment with a phototoxic dose of UVA and topical 8-methoxypsoralen.

Abstract

Twenty-five patients with alopecia totalis (AT) or alopecia universalis and 124 patients with alopecia areata (AA) were treated with photochemotherapy, combining topical 8-methoxypsoralen (8-MOP) with UV irradiation of the scalp at a phototoxic dose. The mean energy required was 15 J/cm2 for AA and 42 J/cm2 for AT. Ninety-four patients had multiple bald patches and 12 with AT had complete or > 50% hair regrowth. Positive treatment results did not seem to depend on the age of onset or the duration of the disease. Few side-effects of topical psoralens plus UVA (PUVA) treatment were noted, except a for few days of slight erythema caused by the high dose of UV.

• Authors: Z Mohamed, A Bhouri, A Jallouli, B Fazaa, M R Kamoun, I Mokhtar
• Journal: Journal of the European Academy of Dermatology and Venereology : JEADV (J Eur Acad Dermatol Venereol) Vol. 19 Issue 5 Pg. 552-5 (Sep 2005) ISSN: 0926-9959 [Print] England
• PMID: 16164707 (Publication Type: Clinical Trial, Comparative Study, Journal Article)

Chemical References

• Methoxsalen

Topics

• Administration, Topical
• Adolescent
• Adult
• Aged
• Alopecia Areata (diagnosis, drug therapy)
• Child
• Esthetics
• Female
• Follow-Up Studies
• Humans
• Male
• Methoxsalen (therapeutic use)
• Middle Aged
• PUVA Therapy (methods)
• Patient Satisfaction
• Photochemotherapy (methods)
• Prospective Studies
• Risk Assessment
• Severity of Illness Index
• Treatment Outcome