Abstract | CONTEXT: OBJECTIVE: The objective of the study was to clarify whether 1,25( OH)2D indeed inhibits circulating levels of PTH and influences bone turnover, even in a patient with primary hyperparathyroidism. DESIGN, SETTING, AND PATIENT: INTERVENTIONS AND MAIN OUTCOME MEASURES: RESULTS: Serum Ca and PTH levels significantly decreased after parathyroid surgery, whereas serum 1,25( OH)2D levels remained high. Prednisolone administration promptly decreased serum 1,25( OH)2D levels and reciprocally increased PTH levels despite consistent serum Ca levels either before or after surgery. PTH levels were negatively correlated with serum 1,25( OH)2D levels before and after surgery. Urine N-telopeptides, serum osteocalcin, and bone-type alkaline phosphatase all decreased to physiological ranges after parathyroid surgery. CONCLUSIONS: These results suggest that 1,25( OH)2D indeed inhibits the production of PTH not to exacerbate hypercalcemia in a patient with primary hyperparathyroidism. Furthermore, PTH but not 1,25( OH)2D may primarily be involved in the stimulation of bone turnover.
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Authors | Yuka Kinoshita, Manabu Taguchi, Akira Takeshita, Daishu Miura, Shinji Tomikawa, Yasuhiro Takeuchi |
Journal | The Journal of clinical endocrinology and metabolism
(J Clin Endocrinol Metab)
Vol. 90
Issue 12
Pg. 6727-31
(Dec 2005)
ISSN: 0021-972X [Print] United States |
PMID | 16159932
(Publication Type: Case Reports, Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Biomarkers
- Hormones
- Parathyroid Hormone
- Vitamin D
- 1,25-dihydroxyvitamin D
- Calcium
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Topics |
- Aged
- Biomarkers
- Bone and Bones
(metabolism)
- Calcium
(blood)
- Female
- Hormones
(blood)
- Humans
- Hyperparathyroidism, Primary
(blood, complications, metabolism)
- Osmolar Concentration
- Parathyroid Hormone
(antagonists & inhibitors, blood)
- Sarcoidosis
(complications)
- Vitamin D
(analogs & derivatives, metabolism)
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