[Clinical significance of protein Z detection in patients with malignant tumors].

Abstract

BACKGROUND & OBJECTIVE:

The blood of the patients with malignant tumors is in hypercoagulable state; its correlation to tumor migration evokes more and more attentions. Protein Z (PZ), a newly found anti-coagulation factor, is a vitamin K-dependent plasma protein which is synthesized by the liver. Its structure is very similar to the vitamin K-dependent coagulation factors, such as FXII, FIX, FX, and protein C, but its physiologic function and clinical significance are unclear. The alteration of PZ level correlates with the increased risk of coagulating abnormality-caused diseases, but its alteration in solid tumors is seldom reported. This study was to explore clinical significance of PZ and the correlation of PZ level to FXII:C; FIX:C and FX:C levels in malignant tumors.

METHODS:

Plasma levels of PZ, FXII:C, FIX:C, FX:C, and FX:Ag of 80 patients with malignant tumors (MT group) and 80 healthy donors (control group) were detected; their correlations were analyzed.

RESULTS:

The level of PZ was significantly lower in MT group than in control group [(1 210.89+/-251.13) ng/ml vs. (2,378.83+/-429.51) ng/ml, P<0.01], but the levels of FXII:C, FX:C, and FX:Ag were significantly higher in MT group than in control group [(162.42+/-36.57)% vs. (114.78+/-28.96)%, (120.27+/-33.96)% vs. (79.23+/-19.46)%, and (133.66+/-35.51)% vs. (93.0+/-17.73)%, P<0.01]. The levels of FIX:C were (119.86+/-56.38)% in MT group, and (109.21+/-36.46)% in control group (P>0.05). The level of PZ was negatively correlated with the levels of FXII:C; FX:C, and FX:Ag (P<0.01), but had no correlation with the level of FIX:C (P>0.05). The level of PZ was significantly lower in stage III-IV (locally advanced stage-advanced stage) patients than in stage II patients [(998.32+/-117.72) ng/ml vs. (1,326.69+/-245.70) ng/ml, P<0.01], but the levels of FXII:C, FX:C, and FX:Ag were significantly higher in stage III-IV patients than in stage II patients [(206.76+/-28.63)% vs. (136.09+/-26.80)%, (162.53+/-32.92)% vs. (101.89+/-23.44)%, (168.03+/-25.97)% vs. (105.41%+/-13.86)%, P<0.01].

CONCLUSIONS:

PZ level is obviously decreased in the patients with malignant tumors, and negatively correlated with FXII:C, FX:C, and FX:Ag. PZ level descends along with the progression of malignant tumors, and maybe a poor prognostic factor of malignant tumors.

• Authors: Yi Shang, Xue-Yi Pan, Cai-Ping Ding, Xin-Mei Yang, Xiao-Yan Cai, Ying Ding, Rou-Ling Zhang
• Journal: Ai zheng = Aizheng = Chinese journal of cancer (Ai Zheng) Vol. 24 Issue 9 Pg. 1144-7 (Sep 2005) China
• PMID: 16159443 (Publication Type: English Abstract, Journal Article)

Chemical References

• Biomarkers, Tumor
• Blood Proteins
• Protein C
• plasma protein Z
• Factor VII
• Factor IX
• Factor X

Topics

• Adult
• Aged
• Aged, 80 and over
• Biomarkers, Tumor
• Blood Proteins (metabolism)
• Breast Neoplasms (metabolism, pathology)
• Carcinoma, Non-Small-Cell Lung (metabolism, pathology)
• Colorectal Neoplasms (metabolism, pathology)
• Factor IX (metabolism)
• Factor VII (metabolism)
• Factor X (metabolism)
• Female
• Humans
• Lung Neoplasms (metabolism, pathology)
• Lymphoma (metabolism, pathology)
• Male
• Middle Aged
• Neoplasm Staging
• Prognosis
• Protein C (metabolism)