KL-6 and surfactant proteins A and D in serum and bronchoalveolar lavage fluid in patients with acute eosinophilic pneumonia.

Abstract

OBJECT:

The serum levels of KL-6, surfactant protein A (SP-A), and SP-D are useful biomarkers and prognostic factors for the activity of interstitial pneumonias. The aim of this study was to determine the clinical roles of the levels of KL-6, SP-A, and SP-D in the serum and bronchoalveolar lavage fluid (BALF) of patients with acute eosinophilic pneumonia (AEP).

MATERIALS AND METHODS:

We researched 5 cases of AEP. The levels of KL-6, SP-A, and SP-D in the sera and BALF of those patients were measured by enzyme-linked immunosorbent assay.

RESULTS:

KL-6 levels in BALF did not differ between AEP patients and the healthy control group, while SP-A and SP-D levels in BALF were significantly higher in the AEP patients than in the healthy control group. In sera, AEP patients had significantly higher than normal levels of SP-A and SP-D, but not of KL-6. Only in sera there was a positive correlation between SP-A and SP-D, but no apparent correlations in BALF and also between KL-6 and the others. Furthermore, the BALF levels of SP-D, but not of SP-A or KL-6, statistically correlated with the concentration of albumin in BALF. After clinical improvement, the elevated levels of serum SP-A or SP-D in AEP patients decreased until normal levels were reached within 2 months.

CONCLUSION:

These results suggest that the serum or BALF levels of SP-D appear to be more sensitive than those of SP-A or KL-6 at reflecting the inflammatory response in AEP lungs.

• Authors: Tadahisa Daimon, Shunji Tajima, Katsuhisa Oshikawa, Masashi Bando, Shoji Ohno, Yukihiko Sugiyama
• Journal: Internal medicine (Tokyo, Japan) (Intern Med) Vol. 44 Issue 8 Pg. 811-7 (Aug 2005) ISSN: 0918-2918 [Print] Japan
• PMID: 16157978 (Publication Type: Journal Article)

Chemical References

• Antigens
• Antigens, Neoplasm
• Biomarkers
• Glycoproteins
• MUC1 protein, human
• Mucin-1
• Mucins
• Pulmonary Surfactant-Associated Protein A
• Pulmonary Surfactant-Associated Protein D

Topics

• Acute Disease
• Adolescent
• Adult
• Antigens (blood, metabolism)
• Antigens, Neoplasm
• Biomarkers (analysis, blood)
• Bronchoalveolar Lavage Fluid (chemistry)
• Case-Control Studies
• Female
• Glycoproteins (blood, metabolism)
• Humans
• Male
• Mucin-1
• Mucins (blood, metabolism)
• Prognosis
• Pulmonary Eosinophilia (blood, metabolism)
• Pulmonary Surfactant-Associated Protein A (blood, metabolism)
• Pulmonary Surfactant-Associated Protein D (blood, metabolism)
• Retrospective Studies