Metabolism of pregnenolone by human breast cancer. Evidence for 17 alpha-hydroxylase and 17,20-lyase.

Abstract	The metabolism of 7-(3)H-pregnenolone was studied in vitro using 16 human breast carcinomas. All mammary tumors transformed pregnenolone to progesterone. All estrogen receptor poor tumors and 4 out of 8 estrogen receptor rich tumors converted pregnenolone to 17-hydroxypregnenolone. Five estrogen receptor poor tumors showed the presence of 17,20-lyase as evidenced by formation of dehydroepiandrosterone and androstenedione. In two estrogen receptor poor tumors, conversions of pregnenolone to progesterone, 17-hydroxy pregnenolone, dehydroepiandrosterone, androstenedione and finally to estradiol was documented, providing a hypothetical pathway for steroid metabolism in human breast cancer. The conversion of pregnenolone to 17-hydroxypregnenolone was significantly less in receptor rich tumors and was totally absent in 4 receptor rich tumors with estrogen receptors of over 45 fmol/mg protein.
Authors	Y J Abul-Hajj, R Iverson, D T Kiang
Journal	Steroids (Steroids) Vol. 34 Issue 7 Pg. 817-27 (Dec 1979) ISSN: 0039-128X [Print] United States
PMID	161434 (Publication Type: Journal Article, Research Support, U.S. Gov't, P.H.S.)
Chemical References	Hydroxyprogesterones Receptors, Estrogen 17-alpha-Hydroxypregnenolone Androstenedione Dehydroepiandrosterone Progesterone Estradiol Pregnenolone Cytochrome P-450 Enzyme System Steroid Hydroxylases Steroid 17-alpha-Hydroxylase pregnenolone 17-alpha-hydroxylase Aldehyde-Lyases
Topics	17-alpha-Hydroxypregnenolone (biosynthesis) Aged Aldehyde-Lyases (metabolism) Androstenedione (biosynthesis) Breast Neoplasms (metabolism) Cytochrome P-450 Enzyme System Dehydroepiandrosterone (biosynthesis) Estradiol (biosynthesis) Female Humans Hydroxyprogesterones (metabolism) Menopause Middle Aged Pregnenolone (metabolism) Progesterone (biosynthesis) Receptors, Estrogen (physiology) Steroid 17-alpha-Hydroxylase (metabolism) Steroid Hydroxylases (metabolism)

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